Pathogen intelligence
نویسنده
چکیده
Different species inhabit different sensory worlds and thus have evolved diverse means of processing information, learning and memory. In the escalated arms race with host defense, each pathogenic bacterium not only has evolved its individual cellular sensing and behavior, but also collective sensing, interbacterial communication, distributed information processing, joint decision making, dissociative behavior, and the phenotypic and genotypic heterogeneity necessary for epidemiologic success. Moreover, pathogenic populations take advantage of dormancy strategies and rapid evolutionary speed, which allow them to save co-generated intelligent traits in a collective genomic memory. This review discusses how these mechanisms add further levels of complexity to bacterial pathogenicity and transmission, and how mining for these mechanisms could help to develop new anti-infective strategies.
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1 New England Complex Systems Institute, Cambridge, Massachusetts 02138. 2 Instituto de Física GlebWataghin, Universidade Estadual de Campinas, 13083-970 Campinas, São Paulo, Brazil; e-mail: [email protected] 3 MIT Artificial Intelligence Laboratory, 200 Technology Square, Cambridge, Massachusetts 02139. 4 Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachu...
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2014